研究方向:
实验室致力于研究陆生种子植物对于陆地土壤环境的适应性,集中研究植物种子在土壤中萌发,幼苗向上生长破土而出,以及出土后见光变绿存活的分子调控机制。主要研究内容有:
1)不同土壤环境对植物种子萌发,幼苗生长发育及出土存活的调控机理;
2)出土过程中多种环境因子与植物内源激素共同调控幼苗形态建成的分子网络;
3)叶绿素合成,叶绿体发育,与幼苗抗光氧化损伤分子机制;
4)植物感受土壤机械压力(植物触觉)的蛋白质机器以及机械压力调控植物生长发育的信号传导通路。
代表性科研论文:
1. Zhao Y.#, Shi H.#, Pan Y.#, Lyu M., Yang Z., Kou X., Deng X., Zhong S.*, Sensory circuitry controls cytosolic calcium-mediated phytochrome B phototransduction, Cell, 2023, 186: 1230-1243. (#equal contribution, *corresponding author)
2. Chen D.#, Lyu M.#, Kou X., Li J., Yang Z., Gao L., Li Y., Fan L., Shi H., Zhong S.*, Integration of light and temperature sensing by liquid-liquid phase separation of phytochrome B, Molecular Cell, 2022, 82: 3015-3029. (Cover story)
3. Wu Q., Li Y., Lyu M., Luo Y., Shi H., Zhong S.*, Touch-induced seedling morphological changes are determined by ethylene-regulated pectin degradation, Science Advances, 2020, 6 (48), eabc9294.
4. Wu Q., Kuang K., Lyu M., Zhao Y., Li Y., L J., Pan Y., Shi H., Zhong S.*, Allosteric deactivation of PIFs and EIN3 by microProteins in light control of plant development, PNAS, 2020, 117: 18858-18868.
5. Lyu M.#, Shi H.#, Li Y., Kuang K., Yang Z., Li J., Chen D., Li Y., Kou X., Zhong S.*, Oligomerization and photo-deoligomerization of HOOKLESS1 controls plant differential cell growth, Developmental Cell, 2019, 51: 78-88.
6. Shi H.#, Lyu M.#, Luo Y.#, Liu S.#, Li Y., He H., Wei N., Deng X.W.*, Zhong S.*, Genome-wide regulation of light-controlled seedling morphogenesis by three families of transcription factors, PNAS, 2018,115: 6482-6487.
7. Liu X., Liu R., Li Y., Shen X., Zhong S.*, Shi H.*, EIN3 and PIF3 Form an Interdependent Module that Represses Chloroplast Development in Buried Seedling, Plant Cell, 2017,29: 3051-3067.
8. Shi H.#, Shen X.#, Liu R., Xue C., Wei N., Deng X.W.*, Zhong S.*, The red light receptor phytochrome B directly enhances substrate-E3 ligase interactions to attenuate ethylene responses, Developmental Cell, 2016,39:597-610. (cover story)
9. Shi H., Liu R., Xue C., Shen X., Wei N., Deng X.W.*, Zhong S.*, Seedlings Transduce the Depth and Mechanical Pressure of Covering Soil Using COP1 and Ethylene to Regulate EBF1/EBF2 for Soil Emergence, Current Biology, 2016, 26: 139-149.
10. Shi H., Wang X., Mo X., Tang C., Zhong S.*, Deng X.W.*, Arabidopsis DET1 degrades HFR1 but stabilizes PIF1 to precisely regulate seed germination, PNAS, 2015, 112 (12): 3817-3822.
11. Zhong S., Shi H., Xue C., Wei N., Guo H., Deng X.W.*, Ethylene-orchestrated circuitry coordinates a seedling`s response to soil cover and etiolated growth, PNAS, 2014, 111 (11): 3913-20.
12. Shi H.#, Zhong S.#, Mo X.#, Liu N., Nezames C.D., Deng X.W.*, HFR1 sequesters PIF1 to govern the transcrIptional network underlying light-initiated seed germination in Arabidopsis, Plant Cell, 2013, 25: 3770–3784.
13. Zhong S., Shi H., Xue C., Wang L., Xi Y., Li J., Quail P.H., Deng X.W.*, Guo H.*, A molecular framework of light-controlled phytohormone action in Arabidopsis, Current Biology, 2012, 22: 1530–1535.
14. Zhong S., Zhao M., Shi T., Shi H., An F., Zhao Q., Guo H.*, EIN3/EIL1 cooperate with PIF1 to prevent photo-oxidation and promote greening of Arabidopsis seedlings, PNAS, 2009, 106 (50): 21431