研究方向：
本课题组致力于开展维数可控的多功能磁性纳米复合材料的化学设计、控制合成及其在生物医学领域的应用探索研究。围绕临床诊疗面临的重大挑战，开展如下研究：
(1)磁纳纳米诊疗探针的构筑及其性能评价；
(2)智能药物递送系统的设计及其应用研究；
(3)新型纳米生物技术（如多功能纳米酶、纳米机器人等）的开发及其应用拓展。
代表性科研论文：
(1) S. Wang, Z. Wang, Z. Li, X. Zhang, H. Zhang, T. Zhang, X. Meng, F. Sheng, Y. Hou*, Amelioration of systemic antitumor immune responses in cocktail therapy by immunomodulatory nanozymes. Sci. Adv. 8, eabn3883 (2022).
(2) J. Wang, Z. Sun, S. Wang, C. Zhao, J. Xu, S. Gao, M. Yang, F. Sheng, S Gao, Y. Hou*, Biodegradable Ferrous Sulfide-Based Nanocomposites for Tumor Theranostics through Specific Intratumoral Acidosis-Induced Metabolic Symbiosis Disruption. J. Am. Chem. Soc. 144, 19884−19895 (2022). (Journal Cover)
(3) S. Wang, J. Xu, W. Li, S. Sun, S. Gao, Y. Hou*, Magnetic nanostructures: rational design and fabrication strategies toward diverse applications. Chem. Rev. 122, 5411−5475 (2022). (Journal Cover)
(4) Z. Sun, Z. Wang, T. Wang, J. Wang, H. Zhang, Z. Li, S. Wang, F. Sheng, J. Yu, Y. Hou*, Biodegradable MnO-Based Nanoparticles with Engineering Surface for Tumor Therapy: Simultaneous Fenton-Like Ion Delivery and Immune Activation. ACS Nano 16, 11862–11875 (2022).
(5) S. Wang, Z. Wang, Z. Li, J. Xu, X. Meng, Z. Zhao, Y. Hou*, A Catalytic Immune Activator Based on Magnetic Nanoparticles to Reprogram the Immunoecology of Breast Cancer from “Cold” to “Hot” State. Adv. Healthcare Mater. 11, 2201240 (2022).
(6) Z. Wang, S. Wang, X. Zhang, Z. Li, Z. Ali, D. Yu, H. Zhang, F. Sheng, S. Gao, Y. Hou*, Temperature and Tumor Microenvironment Dual Responsive Mesoporous Magnetic Nanospheres for Magnetothermal Effect Induced Cancer Theranostics. CCS Chem. 5, 469-485 (2022).
(7) S. Wang, Z. Sun, and Y. Hou*, Engineering nanoparticles toward the modulation of emerging cancer immunotherapy. Adv. Healthcare Mater. 10, 2000845 (2021).
(8) Z. Wang, Z. Li, Z. Sun, S. Wang, Z. Ali, S. Zhu, S. Liu, Q. Ren, F. Sheng, B. Wang, Y. Hou*, Visualization nanozyme based on tumor microenvironment “unlocking” for intensive combination therapy of breast cancer. Sci. Adv. 6, eabc8733 (2020).
(9) Z. Wang, Y. Ju, Z. Ali, H. Yin, F. Sheng*, J. Lin, B. Wang*, Y. Hou*, Near-Infrared Light and Tumor Microenvironment Dual Responsive Size-Switchable Nanocapsules for Multimodal Tumor Theranostics. Nature Commun 10, 4418 (2019).
(10) J. Yu, F. Zhao, W. Gao, X. Yang, Y. Ju, L. Zhao, W. Guo, J. Xie, X. Liang, X. Tao, J. Li, Y. Ying, W. Li, J. Zheng, L. Qiao, S. Xiong, X. Mou, S. Che*, Y. Hou*, Magnetic Reactive Oxygen Species Nanoreactor For Switchable Magnetic Resonance Imaging Guided Cancer Therapy Based on pH-Sensitive Fe5C2@Fe3O4 Nanoparticles. ACS Nano 13, 10002−10014 (2019). (Journal Cover)
