研究方向：
孙育杰教授本科和硕士毕业于中国科学技术大学化学系，博士毕业于匹兹堡大学化学系，博士后于宾夕法尼亚大学纳米/生物交叉研究中心。现为北京大学终身教授、博雅特聘教授、未来技术学院 • 国家生物医学成像科学中心（NBIC）、生物医学前沿创新中心（BIOPIC）、膜生物学国家重点实验室研究员、博士生导师，获得Elsevier Scopus高引青年科学家奖、青年海外高层次人才引进计划、国家自然科学基金委杰出青年科学基金，担任多模态跨尺度生物医学成像国家重大科技基础设施副总工程师。
孙育杰教授领导的单分子与活细胞动态过程实验室长期致力发展以单分子、超分辨荧光成像为主的单分子生物物理技术，同时开展细胞超微结构与功能方面的研究，特别是基因组三维结构与功能、蛋白-DNA互作，先后主持基金委重大仪器研发和科技部863计划等10个国家级科研项目，在Science、 NatureCellBiology、PNAS等期刊发表相关文章100多篇，其中一作文章11篇，通讯作者文章43篇。针对细胞成像面临的背景高、分辨率不足的问题，团队开发了一系列探针、标记及成像方法，为研究亚细胞精细结构与动态过程提供了重要工具。利用这些工具，团队开展对染色质结构与功能的系统深入研究。相对于测序等研究手段，成像技术提供了独特视角，揭示了染色质高级结构调控转录、复制等关键生物学过程的机制，获得了国际学界的高度关注。
代表性科研论文：
1. Hongchen Zhang, Shipeng Shao, Yong Zeng, Xiaotian Wang, Yizhi Qin, Qiunan Ren, Shengqi Xiang, Yuxin Wang, Junyu Xiao & Yujie Sun, Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock, Nature Cell Biology, 2022, 24, 340–352
2. Yongzheng Li, Boxin Xue, Mengling Zhang, Liwei Zhang, Yingping Hou, Yizhi Qin, Haizhen Long, Qian Peter Su, Yao Wang, Xiaodong Guan, Yanyan Jin, Yuan Cao, Guohong Li, Yujie Sun (2021). "Transcription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency." Genome Biol 22(1): 206.
3. Qin, J., Guo, Y., Xue, B., Shi, P., Chen, Y., Su, Q.P., Hao, H., Zhao, S., Wu, C., Yu, L., Li, D. *, Sun, Y.*, ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation, Nat Comm. 2020, 11(1): 4471
4. Qian Peter Su*, Ziqing Winston Zhao*, Luming Meng, Miao Ding, Weiwei Zhang, Yongzheng Li, Mengzhu Liu, Rongqin Li, Yi-Qin Gao, Xiaoliang Sunney Xie*, and Yujie Sun* Super-resolution Imaging Reveals Spatio-temporal Propagation of Human Replication Foci Mediated by CTCF-organized Chromatin Structures. Proc. Natl. Acad. Sci. USA 2020, 117 (26): 15036-15046 https://doi.org/10.1073/pnas.2001521117
5. Mian Wei, Xiaoying Fan, Miao Ding, Ruifeng Li, Shipeng Shao, Yingping Hou, Shaoshuai Meng, Fuchou Tang, Cheng Li, Yujie Sun, Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering, Science Advances 2020; 6 : eaay6515
6. Hao, H., Niu, J., Xue, B., Su, Q. P., Liu, M., Yang, J., Qin, J., Zhao, S., Wu, C.*, Sun, Y.*, Golgi-associated microtubules are fast cargo tracks and required for persistent cell migration, EMBO Rep 2020, 21:e48385.
7. Xuanze Chen#, Rongqin Li#, Zhihe Liu#, Kai Sun, Zezhou Sun, Danni Chen, Gaixia Xu, Peng Xi, Changfeng Wu*, & Yujie Sun*, “Photoblinking small semiconductor polymer dots for fluorescence nanoscopy”, Adv. Mater. 2017, 29(5):1604850. (VIP paper & cover story) (# equal contribution,*co-corresponding)
8. Sheng Wang#, Xuanze Chen#, Lei Chang#, Ruiying Xue, Haifeng Duan, and Yujie Sun*, “GMars-Q Enables Long-Term Live-Cell Parallelized Reversible Saturable Optical Fluorescence Transitions Nanoscopy”, ACS Nano 2016, 10:9136–9144 (cover story)（# equal contribution）
9. Xuanze Chen#, Mian Wei#, M. Mocarlo Zheng#, Jiaxi Zhao, Huiwen Hao, Lei Chang, Peng Xi, and Yujie Sun*, “Study of RNA Polymerase II Clustering inside Live-Cell Nuclei Using Bayesian Nanoscopy”, ACS Nano 2016, 10: 2447–54. (#equal contribution)
10. Shipeng Shao, Weiwei Zhang, Huan Hu, Boxin Xue, Jinshan Qin, Chaoying Sun, Yuao Sun, Wensheng Wei, Yujie Sun*, “Long-term Dual-color Tracking of Genomic Loci by Modified sgRNAs of the CRISPR/Cas9 System”, Nucleic Acids Res. 2016, 44: e86
11. Zhen Liu, Dong Xing, Qian Su, Xinyu Kong, Jiamei Zhang,Boxin Xue, Hao Sun, Sheng Wang, Yile Tao, Yujie Sun*, “Super-resolution Imaging and Tracking of Protein-Protein Interaction in Subdiffraction Cellular Space”, Nature Comm. 2014, 5:4443-49
12. Sangjin Kim#, Erik Broströmer#, Dong Xing#, Jianshi Jin#, Shasha Chong, Hao Ge, Siyuan Wang, Chan Gu, Lijiang Yang, Yi Qin Gao, Xiao-dong Su*, Yujie Sun*, X. Sunney Xie*, “Probing Allostery Through DNA”, Science 2013, 339:816-819 (#equal contribution, *co-corresponding)
13. Yujie Sun, Osamu Sato, Felix Ruhnow, Mark E. Arsenault, Mitsuo Ikebe, and Yale E. Goldman*&, “Single Molecule Stepping and Structural Dynamics of Myosin X”, Nat. Struct. Mol. Biol. 2010, 17: 485-491.
14. Yujie Sun, Jennine D. McKenna, John M. Murray, E. Michael Ostap and Yale E. Goldman*&, “Parallax: High Accuracy Three-Dimensional Single Molecule Tracking Using Split Images”, Nano Letters 2009, 9: 2676-2682.
Yujie Sun, Harry W. Schroeder III, John F. Beausang, Kazuaki Homma, Mitsuo Ikebe, and Yale E. Goldman*&, “Myosin VI walks “wiggly” on actin with large and variable tilting”, Mol Cell 2007,
