研究方向
我们对癌症的理解已经从肿瘤细胞的内部调控扩展到肿瘤与微环境之间复杂的相互作用，并认识到癌症是一种全身系统性疾病。随着肿瘤对全身的影响，它不仅能诱导肝脏与肌肉代谢功能的失调，还导致了免疫系统功能紊乱；肿瘤不仅能直接调控远端组织器官的功能，还能通过调节组织器官之间的相互作用而破坏机体稳态。机体稳态的失衡既影响了抗肿瘤治疗的疗效和预后，也降低了癌症患者的生存率和生活质量。然而，我们对肿瘤诱导的宿主全身系统性病变机理的了解仍然匮乏，这严重阻碍了抗肿瘤治疗策略的发展，限制了治疗癌症及其并发症的效果。
本实验室从免疫、代谢及恶病质这三个方向深入探究肿瘤诱发宿主体内多组织、器官功能性病变的机理，为治疗癌症及其并发症，尤其是恶病质等提供重要的治疗靶点，以期提高患者的生存率和生活质量。
代表性论文
1.Gang Wang, Jianlong Li, Linda Bojmar, Haiyan Chen, Zhong Li, Gabriel C. Tobias, Mengying Hu, Edwin A. Homan, Serena Lucotti, Fengbo Zhao, Valentina Posada, Peter R. Oxley, Michele Cioffi, Han Sang Kim, Huajuan Wang, Pernille Lauritzen, Nancy Boudreau, Zhanjun Shi, Christin E. Burd, Jonathan H. Zippin, James C. Lo, Geoffrey S. Pitt, Jonathan Hernandez, Constantinos P. Zambirinis, Michael A. Hollingsworth, Paul M. Grandgenett, Maneesh Jain, Surinder K. Batra, Dominick J. DiMaio, Jean L. Grem, Kelsey A. Klute, Tanya M. Trippett, Mikala Egeblad, Doru Paul, Jacqueline Bromberg, David Kelsen, Vinagolu K. Rajasekhar, John H. Healey, Irina R. Matei, William R. Jarnagin, Robert E. Schwartz, Haiying Zhang, David Lyden. Tumour extracellular vesicles and particles induce liver metabolic dysfunction.Nature2023 June 8; 618, 374–382.
· Highlighted inNature Reviews Cancer23, 510 (2023)
· Highlighted inCancer Discovery(2023)https://doi.org/10.1158/2159-8290.CD-RW2023-086
2.Gang Wang, Anup K. Biswas, Wanchao Ma, Manoj Kandpal, Courtney Coker, Paul M. Grandgenett, Rinku Jain, Kurenai Tanji, Sara Lόpez-Pintado, Alain Borczuk, Doreen Hebert, Supak Jenkitkasemwong, Shintaro Hojyo, Ramana V. Davuluri, Mitchell D. Knutson, Toshiyuki Fukada, Swarnali Acharyya.Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle.Nature Medicine2018 Jun;24 (6), 770-781.
· Highlighted inNature Reviews Cancer18, 467 (2018)
3.Gang Wang,Candia M. Kenific, Grace Lieberman, Haiying Zhang, David Lyden.Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles. In: Acharyya, S. (eds) The Systemic Effects of Advanced Cancer.Springer, Cham. (2022) https://doi.org/10.1007/978-3-031-09518-4_2.
4.Gang Wang, Haiying Zhang, David Lyden.Tumour-regulated anorexia preceding cachexia.Nature Cell Biology2021 Feb; 23, 111-113.
5.Candia M.Kenific*,Gang Wang*,David Lyden.Tumor extracellular vesicles impede interferon alert responses.Cancer Cell2019 Jan 14;34 (1), 3-5. (*Co-First authors)
6.GangWang, Qing Jiang, Chuanmao Zhang. The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle.Journal of Cell Science2014 Oct 1; 127 (19), 4111-4122.
7.GangWang, Qiang Chen, Xiaoyan Zhang, Boyan Zhang, Xiaolong Zhuo, Junjun Liu, Qing Jiang, Chuanmao Zhang. PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry.Journal of Cell Science2013 Mar 15;126 (6), 1355-1365.
· A featured article inJournal of Cell Science126 (6): e0605 (2013)
· Highlighted inNature Reviews Molecular Cell Biology 14, 131 (2013).
8.Wangfei Chi,Gang Wang, Guangwei Xin, Qing Jiang, Chuanmao Zhang. PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations.Journal of Cell Biology 2021 Jan 4; 220 (1): e202002151.
9. Tingting Zhang, Guangwei Xin, Mingkang Jia, Tenghan Zhuang, Shicong Zhu, Boyan Zhang,Gang Wang, Qing Jiang, Chuanmao Zhang. Plk1 kinase negatively regulates the Hedgehog signaling pathway by phosphorylating Gli1.Journal of Cell Science2019 Jan 22; 132, jcs220384. doi:10.1242/jcs.220384.
10. Boyan Zhang, Tenghan Zhuang, Qiaoyu Lin, Biying Yang, Xiaowei Xu, Guangwei Xin, Shicong Zhu,Gang Wang, Bin Yu, Tingting Zhang, Qing Jiang, Chuanmao Zhang. Patched1-ArhGAP36-PKA-Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation.PNAS2019 Jan 15;116 (3), 874-879.
11. Huabo Chen, Xiaowei Xu, Guopeng Wang, Boyan Zhang,Gang Wang, Guangwei Xin, Junjun Liu, Qing Jiang, Hongyin Zhang, Chuanmao Zhang. CDK4 protein is degraded by anaphase-promoting complex/cyclosome in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells.Journal of Biological Chemistry2017 Jun 16;292(24):10131-10141.
12. Xiaowei Xu, Shijiao Huang, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li, Qing Jiang, Chuanmao Zhang.DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.Nature Communications2017 Apr 27;8:15164.
13. Boyan Zhang,Gang Wang, Xiaowei Xu, Sisi Yang, Tenghan Zhuang, Guopeng Wang, He Ren, Steven Y. Cheng, Qing Jiang, Chuanmao Zhang. DAZ-interacting protein 1 (Dzip1) phosphorylation by Polo-like kinase 1 (Plk1) regulates the centriolar satellites localization of the BBSome during the cell cycle.Journal of Biological Chemistry2017 Jan 27;292(4):1351-1360.
14. Ran Qi, Nan Xu,Gang Wang, He Ren, Si Li, Jun Lei, Qiaoyu Lin, Lihao Wang, Xin Gu, Hongyin Zhang, Qing Jiang, ChuanmaoZhang. Lamin-A/C/LAP2α/BAF1 protein complex regulates the mitotic spindle assembly and positioning.Journal of Cell Science2015 Aug 1; 128(15):2830-41.
15. Si Li, Zhaoxuan Deng, Jingyan Fu, Caiyue Xu, Guangwei Xin, Zhige Wu, Jia Luo,Gang Wang, Shuli Zhang, Boyan Zhang, Fangdong Zou, Qing Jiang, Chuanmao Zhang. Spatial compartmentalization specializes function of Aurora-A and Aurora-B.Journal of Biological Chemistry2015 Jul 10;290(28):17546-58.
16. Boyan Zhang, Tingting Zhang, Guopeng Wang,Gang Wang, Wangfei Chi, Qing Jiang, Chuanmao Zhang.GSK3β-Dzip1-Rab8cascade regulates ciliogenesis after mitosis.PloS Biology2015 Apr;13(4): e1002129.
17. Wenxiang Fu, Hao Chen,Gang Wang, Jia Luo, Zhaoxuan Deng, Guangwei Xin, Nan Xu, Xiao Guo, Jun Lei, Qing Jiang, Chuanmao Zhang.Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly.PNAS2013 Sep 17;110 (38), 15295-15300.
